Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes
نویسندگان
چکیده
منابع مشابه
The apparently very variable potency of the anti-depressant fluoxetine.
The anti-depressant fluoxetine is widely present in the aquatic environment. Typical river concentrations are in the low ng/L range. Many ecotoxicity studies have assessed the effects of this pharmaceutical on a range of aquatic species. Some studies report that ng, or even pg, per litre concentrations cause effects, whereas other studies report that effects only occur when the water concentrat...
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Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) based on the hypothesis that similar plasma concentra...
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BACKGROUND Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism. MATERIALS...
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Introduction: Astrocytes have an important role in many neurodegenerative diseases. Active astrocytes release inflammatory factors such as NO and ILs. Shikonin, a naphthoquinone pigment of Lithospermum erythrorhizon roots has anti-inflammatory and antitumoral effects. The present study aims to investigate the anti-inflammatory and toxic effects of Shikonin on cultured astrocytes. Methods...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2018
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2018.05.036